Nekkar LAB » Gastroenterology

The gastric reflux: the therapeutical role of Marial.

admin — Tue, 03 Jul 2018 08:15:07 +0000

Pubblicato su: Journal of Biological Regulators & Homeostatic Agents Volume 32, No (S2), January-February, 2018

Autori: Aragona SE, Mereghetti G, Ciprandi G.

Abstract: The worldwide relevance of gastroesophageal reflux disease (GERD) has had a considerable increase in recent years. The guidelines for the diagnosis and treatment of GERD are well consolidated and continuously updated. Recently, the extra-esophageal manifestations of reflux have been considered from a multidisciplinary point of view, so the symptoms of the laryngo-pharyngeal reflux (LPR) have been precisely defined. At present, a new Medical Compound (Marial®) has the indication for the treatment of both GERD and LPR. Clinical experience has initially confirmed its effectiveness in both disorders.

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The EMERGE: an Italian Survey- Part I

admin — Tue, 03 Jul 2018 08:21:53 +0000

Titolo: The EMERGE (emerging from Gastroesophageal Reflux): an Italian Survey-I the viewpoint of the Gastroenterologist.

Pubblicato su: Journal of Biological Regulators & Homeostatic Agents Volume 32, No (S2), January-February, 2018

Autori: Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G and the EMERGE Study Group

Abstract: Gastroesophageal reflux disease (GERD) is defined as a “disease that develops when the reflux of stomach contents induces troublesome symptoms and/or complications”. From a therapeutic point of view, many options have been proposed, including proton pump inhibitors (PPI), antihistamines (H2- receptor antagonists), antacid chemical compounds, antireflux barrier (using alginates), prokinetics, inhibitors of gastric sphincters, protection of mucosal tissue, neuromodulators, nociceptor antagonists, lifestyle modification, and surgery. A new medical compound has been recently launched in Italy: Marial® (manufactured by Aurora, Milan, Italy) containing magnesium alginate and E-Gastryal®. The aim of this survey was to analyse the patients’ characteristics and the prescriptive approach considering both the past or current treatments and clinical features during a visit in 56 gastroenterological centers, distributed in the whole of Italy. One thousand eight hundred forty-nine patients (46.5% males, and 53.5% females, mean age 48.59 years) were visited. Patients with positive reflux symptoms index (RSI+) had higher GIS scores than RSI- subjects. PPIs (both as monotherapy or plus add-on) were the most common medication prescribed before the visit. There was a significant change of prescription to Marial® at the visit. More precisely,, Marial® was preferentially prescribed to about a quarter of the patients, particularly to those with lower GIS score, whereas PPI plus add-on option was preferred for patients with higher GIS score. In conclusion, the current experience demonstrated that GERD may be managed considering a patient-centred work-up by using the GIS questionnaire. GIS score may be able to define the medication choice that includes also the new medical compound Marial®.

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The EMERGE: an Italian Survey- Part II

admin — Tue, 03 Jul 2018 08:26:23 +0000

Titolo: The EMERGE (emerging from Gastroesophageal Reflux): an Italian Survey-II the viewpoint of the Gastroenterologist.

Pubblicato su: Journal of Biological Regulators & Homeostatic Agents Volume 32, No (S2), January-February, 2018

Autori: Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G and the EMERGE Study Group

Abstract: Gastroesophageal reflux disease (GERD) is a very common disease, as about a quarter of the Western population has GERD symptoms at least weekly and GERD is the most frequent reason for outpatient gastroenterology consultation. GERD treatment is based on proton pump inhibitor (PPI) use, but PPI may be ineffective in some patients and potentially unsafe if administered for very long time. A new medical compound (Marial®) has been introduced on the Italian market. This product contains magnesium alginate and a phytopolymer: it may be able to repair ulcer/erosion, protect mucosal tissue, and contrast acid contents. The current survey was conducted on a large group of GERD patients visited at 56 Italian gastroenterological offices. Patients were treated with PPI alone, PPI plus add-on, or Marial® for 4 weeks: the choice was decided by each gastroenterologist on the basis of the best practice criterion. A reflux symptoms index (RSI) questionnaire was used to weekly assess the clinical features. Marial® and PPI plus add-on significantly reduced RSI scores, from the second week. Noteworthy, Marial® was more effective than PPI plus add-on. In conclusion, the current survey demonstrated that patients with GERD perceived a significant improvement of GERD symptoms measured by the RSI questionnaire. Marial® was as effective as PPI plus add-on.

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Correlation between the Reflux Finding Score and the GERD Impact Scale

admin — Tue, 03 Jul 2018 08:29:33 +0000

Titolo: Correlation between the Reflux Finding Score and the GERD Impact Scale in patients with Gastroesophageal Reflux Disease. J Biol Reg Mol Ag 2018 (in press)

Pubblicato su: Journal of Biological Regulators & Homeostatic Agents Volume 32, No (S2), January-February, 2018

Autori: Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G and the EMERGE Study Group

Abstract: Gastroesophageal reflux disease (GERD) is a very common disorder. As there is no gold standard diagnostic tool, patient-based strategy is adopted in clinical practice. In this regard, there are questionnaires able to easily and rapidly assess symptom severity directly by the patient. The GERD Impact Scale (GIS) and the Reflux Symptom Index (RSI) have been validated as diagnostic tools in routine clinical care. The present study aimed to correlate RIS values with GIS scores in a large cohort of GERD patients visited at gastroenterological clinics. Globally, 785 subjects (51.2% males, 48.8% females, mean age: 49.59 years) were visited in 56 Italian gastroenterological offices. The current study demonstrates that a GIS value >19 may be a reliable cut-off to define the positivity of the test, and GIS and RSI were significantly correlated. Therefore, both tests may be recommended for GERD patients in clinical practice.

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